Pixel Gun Tower Defense is an action-packed, fast-paced, and intense tower defense title which features many features from popular series like Pixel Gun. The game contains a variety of weapons and turrets that are designed to provide an easy-to-play experience for its users.
The guns inPixel Gun Tower Defense are categorized into different tiers. The best guns in tier SS are Brutal-headhunter and Prototype while Armageddon and Automatic-peacemaker are the most powerful ones in tier S. Some guns in tier A are Poison-darts and Golden-friend. Bone-crusher and Pixel-gun rank in tier B while Grenade-launcher and Sniper-rifle rank in tier C.
SS Tier

| Guns | Tier |
| Brutal-headhunter | SS |
| Prototype | SS |
S Tier

| Guns | Tier |
| Armageddon | S |
| Automatic-peacemaker | S |
| Clc | S |
| Exterminator | S |
| Electromagnetic-cannon | S |
| Tactical-bow | S |
A Tier

| Guns | Tier |
| Poison-darts | A |
| Golden-friend | A |
B Tier

| Guns | Tier |
| Bone-crusher | B |
| Pixel-gun | B |
| Shotgun | B |
| Uzi-uzi | B |
C Tier

| Guns | Tier |
| Sword | C |
| Grenade-launcher | C |
| Sniper-rifle | C |