The following guide will let you know where to find the Waiting Room safe in Resident evil 2 and the combination required to open it.
The waiting room is on the second floor. You will need to move upstairs and enter inside the waiting room, go behind the desk, and you will find a safe there.
You need to use the left D-pad first and go to six. After that, use the right D-pad, and then you will need to hit the left D-pad again. You have to end on the 11, open up the safe, and get a weapon part for Leon and a weapon part for Claire.